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Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of Gd-DTPA-BMA complex.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Jan2013, Vol. 295 Issue 1, p63-66. 4p. 1 Color Photograph, 2 Graphs. - Publication Year :
- 2013
-
Abstract
- In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 295
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 84487061
- Full Text :
- https://doi.org/10.1007/s10967-012-1870-3