Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of Gd-DTPA-BMA complex.

In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer. [ABSTRACT FROM AUTHOR]