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The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial.
- Source :
-
Diabetes, Obesity & Metabolism . Feb2013, Vol. 15 Issue 2, p185-188. 4p. 2 Charts. - Publication Year :
- 2013
-
Abstract
- This study was performed to assess the efficacy of beraprost sodium ( BPS) in painful diabetic peripheral neuropathy ( DPN) in type 2 diabetes mellitus ( T2DM) patients. In this randomized clinical trial, 99 T2DM patients (41% male, age 60 ± 6 years) with DPN but without evidence of peripheral artery disease were randomized to receive either BPS (40 µg, tid) or placebo for 8 weeks. The primary end point was the improvement of the total symptom score ( TSS), temperature rebound ( TR) and nadir to peak ( NP) above baseline. After 8 weeks treatment, the change of TSS in the BPS group showed a significant improvement compared to the placebo group (2.80 ± 2.48 vs. 1.60 ± 1.94 points, p = 0.009). Furthermore, the number of patients who showed signs of improvement in TSS and the proportion of patients with 50% relief of symptom was also significantly greater in the BPS group than in the placebo group (83.7 vs. 62%, p = 0.015, 36.2 vs. 14%, p = 0.009, respectively). In conclusion, treatment with BPS significantly improved TSS over an 8-week period. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14628902
- Volume :
- 15
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diabetes, Obesity & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 84578141
- Full Text :
- https://doi.org/10.1111/dom.12010