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Prevalence of Neuropsychiatric Symptoms in Young-Onset Compared to Late-Onset Alzheimer's Disease - Part 1: Findings of the Two-Year Longitudinal NeedYD-Study.
- Source :
-
Dementia & Geriatric Cognitive Disorders . Jan2013, Vol. 34 Issue 5/6, p319-327. 9p. 4 Charts. - Publication Year :
- 2013
-
Abstract
- Background/Aims: Knowledge about neuropsychiatric symptoms in young-onset Alzheimer's disease (YO-AD) is scarce, but essential to establish a prognosis and plan care for YO-AD patients. The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD). Methods: 98 YO-AD and 123 LO-AD patients and caregivers from two prospective cohort studies were included and assessed every 6 months for 2 years, using the Neuropsychiatric Inventory to evaluate neuropsychiatric symptoms. Results: Over the course of 2 years, the incidence, prevalence and persistence of neuropsychiatric symptoms were in general lower in YO-AD than in LO-AD, specifically for delusions, agitation, depression, anxiety, apathy, irritability and aberrant motor behavior. Frequency of individual symptoms showed large variability in both groups. Within the group of YO-AD patients, apathy was the most prevalent symptom. Conclusion: Neuropsychiatric symptoms, notably apathy, should be paid appropriate attention to in the diagnosis and treatment of YO-AD patients. Further research is needed to gain insight into the mechanisms underlying the differences in neuropsychiatric symptoms between YO-AD and LO-AD. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *AGE factors in disease
*ALZHEIMER'S disease
*ANALYSIS of variance
*ANXIETY
*CAREGIVERS
*CHI-squared test
*COMPARATIVE studies
*DELUSIONS
*MENTAL depression
*LONGITUDINAL method
*NEUROPSYCHOLOGICAL tests
*MOTIVATION (Psychology)
*NEUROLOGIC manifestations of general diseases
*PSYCHOMOTOR disorders
*RESEARCH funding
*T-test (Statistics)
*AGITATION (Psychology)
*SECONDARY analysis
*DISEASE incidence
*REPEATED measures design
*DISEASE prevalence
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 14208008
- Volume :
- 34
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Dementia & Geriatric Cognitive Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 84684341
- Full Text :
- https://doi.org/10.1159/000342824