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Induction of Protective Anti-CTL Epitope Responses against HER-2-Positive Breast Cancer Based on Multivalent T7 Phage Nanoparticles.
- Source :
-
PLoS ONE . Nov2012, Vol. 7 Issue 11, Special section p1-12. 12p. - Publication Year :
- 2012
-
Abstract
- We report here the development of multivalent T7 bacteriophage nanoparticles displaying an immunodominant H-2kd- restricted CTL epitope derived from the rat HER2/neu oncoprotein. The immunotherapeutic potential of the chimeric T7 nanoparticles as anti-cancer vaccine was investigated in BALB/c mice in an implantable breast tumor model. The results showed that T7 phage nanoparticles confer a high immunogenicity to the HER-2-derived minimal CTL epitope, as shown by inducing robust CTL responses. Furthermore, the chimeric nanoparticles protected mice against HER-2-positive tumor challenge in both prophylactic and therapeutic setting. In conclusion, these results suggest that CTL epitope-carrying T7 phage nanoparticles might be a promising approach for development of T cell epitope-based cancer vaccines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLUCOCORTICOID receptors
*CYCLOBUTANE
*TREES
*PLANT species
*PROTEIN binding
*SODIUM
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 84716255
- Full Text :
- https://doi.org/10.1371/journal.pone.0049539