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Mechanisms behind Functional Avidity Maturation in T Cells.
- Source :
-
Clinical & Developmental Immunology . 2012, p1-8. 8p. 1 Diagram, 2 Charts. - Publication Year :
- 2012
-
Abstract
- During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional aviditymaturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*IMMUNE response
*ANTIBODY formation
*ANTIGENS
*B cells
Subjects
Details
- Language :
- English
- ISSN :
- 17402522
- Database :
- Academic Search Index
- Journal :
- Clinical & Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 84745314
- Full Text :
- https://doi.org/10.1155/2012/163453