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HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type IIMixed Cryoglobulinemia: A Concurrent Pathogenetic Role.
- Source :
-
Clinical & Developmental Immunology . 2012, p1-11. 11p. 1 Diagram, 1 Chart. - Publication Year :
- 2012
-
Abstract
- The association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. Moreover, the same IgV subfamilies are frequently observed in HCV-transformed malignant B-cell clones occasionally complicating MCII. In this paper, we analyze both the humoral and viral counterparts at the basis of cryoglobulins production in HCV-induced MCII, with particular attention reserved to the single IgV subfamilies most frequently involved. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17402522
- Database :
- Academic Search Index
- Journal :
- Clinical & Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 84745492
- Full Text :
- https://doi.org/10.1155/2012/705013