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Hepatitis C Virus Induces Regulatory T Cells by Naturally Occurring Viral Variants to Suppress T Cell Responses.
- Source :
-
Clinical & Developmental Immunology . 2011, p1-15. 15p. 2 Charts, 10 Graphs. - Publication Year :
- 2011
-
Abstract
- Regulatory T cell markers are increased in chronically infected individuals with the hepatitis C virus (HCV), but to date, the induction and maintenance of Tregs in HCV infection has not been clearly defined. In this paper, we demonstrate that naturally occurring viral variants suppress T cell responses to cognate NS3358-375 in an antigen-specific manner. Of four archetypal variants, S370P induced regulatory T cell markers in comparison to NS3358-375-stimulated CD4 T cells. Further, the addition of variantspecific CD4 T cells back into a polyclonal culture in a dose-dependent manner inhibited the T cell response. These results suggest thatHCV is able to induce antigen-specific regulatory T cells to suppress the antiviral T cell response in an antigen-specific manner, thus contributing to a niche within the host that could be conducive to HCV persistence. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*HEPATITIS C virus
*ANTIGENS
*VIRAL antigens
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 17402522
- Database :
- Academic Search Index
- Journal :
- Clinical & Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 84946432
- Full Text :
- https://doi.org/10.1155/2011/806061