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Regulatory T cell kinetics in the peripheral blood of patients with Crohn’s disease
- Source :
-
Human Immunology . Feb2013, Vol. 74 Issue 2, p145-150. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: Estimates of T regulatory cell populations in the periphery of patients with Crohn’s disease are confounded by disease activity and concomitant immunotherapeutic agents known to affect T cell proliferation and survival. We performed deuterium pulse/chase experiments in patients with quiescent Crohn’s disease on no immunotherapy and healthy control subjects to estimate T regulatory cell kinetics. Quantification of deuterated DNA isolated from T cell subsets over 10days was determined by mass spectrophotometry. We demonstrate enhanced proliferation within the T regulatory cell population from patients with Crohn’s disease when compared to non-T regulatory cells and T regulatory cells from healthy control subjects. We speculate that T regulatory cells isolated from the periphery of patients with Crohn’s disease experience persistent antigen stimulation resulting in excess proliferative rates. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 74
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 85007131
- Full Text :
- https://doi.org/10.1016/j.humimm.2012.10.021