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UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates
- Source :
-
Molecular Genetics & Metabolism . Apr2002, Vol. 75 Issue 4, p369. 5p. - Publication Year :
- 2002
-
Abstract
- Uncoupling protein 5 (UCP5) or brain mitochondrial carrier protein-1 (BMCP1) enhances mitochondrial proton leak in vitro and its hepatic and brain expression profiles are modulated by diet and cold exposure in mice. Alternative splicing generates three isoforms: a long form (UCP5L), a short form (UCP5S), and a short form with a 31 amino acid insert (UCP5SI). We investigated the relationship between skeletal muscle UCP5 expression and in vivo energy metabolism in 36 non-diabetic Pima Indians. We determined the expression levels of total UCP5 (UCP5T), and the isoforms UCP5L, UCP5S, and UCP5SI (66.8, 32.5, and 0.8% of UCP5T, respectively). None correlated with body weight or percent body fat. The transcript level of UCP5SI, but not the others, was positively correlated with resting metabolic rate (<f>r=0.38</f>, <f>P=0.02</f>, adjusted for age, sex, fat mass, and fat-free mass) and lipid oxidation rate (adjusted for age, sex, and percent body fat) during a euglycemic clamp with infusion of insulin at a physiologic concentration (<f>r=0.42</f>, <f>P=0.01</f>). [Copyright &y& Elsevier]
- Subjects :
- *CARRIER proteins
*ENERGY metabolism
*PIMA (North American people)
Subjects
Details
- Language :
- English
- ISSN :
- 10967192
- Volume :
- 75
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Molecular Genetics & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 8504175
- Full Text :
- https://doi.org/10.1016/S1096-7192(02)00008-2