Smg1 haploinsufficiency predisposes to tumor formation and inflammation.

Authors :: Roberts, Tara L.
Ho, Uda
Luff, John
Soon Lee, C.
Apte, Simon H.
MacDonald, Kelli P. A.
Raggat, Liza J.
Pettit, Allison R.
Morrow, Carl A.
Waters, Michael J.
Chen, Phil
Woods, Rick G.
Thomas, Gethin P.
Pierre, Liam St.
Farah, Camile S.
Clarke, Raymond A.
Brown, James A. L.
Lavin, Martin F.
Source :: Proceedings of the National Academy of Sciences of the United States of America. 1/22/2013, Vol. 110 Issue 4, p1151-1152. 2p.
Publication Year :: 2013
Abstract: The article offers information on the study regarding the effect of haploinsufficiency of SMG1, a member of phosphoinositide kinase-like kinase proteins, to the formation of tumor and inflammation. It mentions the use of Smg1 mice which shows that insufficient Smg1 increases the risk of papillary lung adenocarcinoma and non-Hodgkin lymphoma that originates from follicular cell. It adds that the Smg1 also has role to the development of chronic inflammatory diseases.

Subjects :: *KINASES
*TUMOR risk factors
*LABORATORY mice
*LUNG cancer risk factors
*LYMPHOMAS
*INFLAMMATION

Language :: English
ISSN :: 00278424
Volume :: 110
Issue :: 4
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 85098123
Full Text :: https://doi.org/10.1073/pnas.1215696110