Back to Search
Start Over
The use of biomonitoring data in exposure and human health risk assessment: benzene case study.
- Source :
-
Critical Reviews in Toxicology . Feb2013, Vol. 43 Issue 2, p119-153. 35p. - Publication Year :
- 2013
-
Abstract
- A framework of 'Common Criteria' (i.e. a series of questions) has been developed to inform the use and evaluation of biomonitoring data in the context of human exposure and risk assessment. The data-rich chemical benzene was selected for use in a case study to assess whether refinement of the Common Criteria framework was necessary, and to gain additional perspective on approaches for integrating biomonitoring data into a risk-based context. The available data for benzene satisfied most of the Common Criteria and allowed for a risk-based evaluation of the benzene biomonitoring data. In general, biomarker (blood benzene, urinary benzene and urinary S-phenylmercapturic acid) central tendency (i.e. mean, median and geometric mean) concentrations for non-smokers are at or below the predicted blood or urine concentrations that would correspond to exposure at the US Environmental Protection Agency reference concentration (30 µg/m3), but greater than blood or urine concentrations relating to the air concentration at the 1 × 10−5 excess cancer risk (2.9 µg/m3). Smokers clearly have higher levels of benzene exposure, and biomarker levels of benzene for non-smokers are generally consistent with ambient air monitoring results. While some biomarkers of benzene are specific indicators of exposure, the interpretation of benzene biomonitoring levels in a health-risk context are complicated by issues associated with short half-lives and gaps in knowledge regarding the relationship between the biomarkers and subsequent toxic effects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10408444
- Volume :
- 43
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 85107313
- Full Text :
- https://doi.org/10.3109/10408444.2012.756455