Three new phenolic compounds from the leaves of Rosa sericea

Abstract: Two new flavonoids, quercetin-3-O-β-d-xylopyranosyl-(1→2)-α-d-ribopyranoside (1) and kaempferol-3-O-β-d-xylopyranosyl-(1→2)-α-d-ribopyranoside (2), and one new phenolic derivative, gallicin-p-O-(6′-O-caffeoyl)-β-d-glucoside (3), together with twelve known compounds were isolated from the leaves of Rosa sericea (Rosaceae family). The structures of the new compounds were established by means of spectroscopic analysis including one- and two-dimensional NMR spectroscopy. Some of the isolated compounds were tested for the cytotoxicity of a breast cancer cell (MCF-7) line. The results showed that rubanthrone A (4) has moderate cytotoxicity against the MCF-7 cell line. [Copyright &y& Elsevier]