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Hypervalent Iodine Mediated para-Selective Fluorination of Anilides.
- Source :
-
Journal of Organic Chemistry . 1/18/2013, Vol. 78 Issue 2, p728-732. 5p. - Publication Year :
- 2013
-
Abstract
- A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 78
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 85403472
- Full Text :
- https://doi.org/10.1021/jo302099d