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Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.
- Source :
-
Clinical & Experimental Dermatology . Mar2013, Vol. 38 Issue 2, p151-153. 3p. 1 Color Photograph. - Publication Year :
- 2013
-
Abstract
- Vibratory angio-oedema is a rare form of physical urticaria characterized by pruriginous weals and angio-oedema at the site of exposure to vibration. Severe treatment-resistant disease can occur, and is associated with significant disability. Therapy with omalizumab, a monoclonal IgG anti-IgE antibody, has been shown to be successful in several types of physical urticaria. We report a patient with vibratory angio-oedema for whom all standard treatments for urticaria, including omalizumab, failed to show a clinical benefit. Finally, ketotifen was tried, and unexpectedly reduced symptoms significantly. Ketotifen may thus represent a therapeutic option in patients with treatment-resistant vibratory angio-oedema. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CASE studies
*KETOTIFEN
*URTICARIA
*IMMUNOGLOBULIN E
Subjects
Details
- Language :
- English
- ISSN :
- 03076938
- Volume :
- 38
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 85412320
- Full Text :
- https://doi.org/10.1111/j.1365-2230.2012.04430.x