A small proportion of people with dementia and neuropsychiatric symptoms experience clinically significant worsening when antidepressants are discontinued.

The article states that a small proportion of people with dementia and neuropsychiatry symptoms experience clinically significant worsening when antidepressants are discontinued. It discusses 25-week double-blind placebo-controlled withdrawal trial in 128 people with AD, vascular dementia or mixed AD/vascular dementia. It was concluded that it is safe to discontinue long-term antidepressants in people having dementia, although clinicians should monitor for worsening depressive symptoms.