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Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?
- Source :
-
Clinical & Developmental Immunology . 2010, p1-9. 9p. - Publication Year :
- 2010
-
Abstract
- Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts, which may limit their capacity to mount an effective tumor-specific CTL response. In particular, the manner in which exogenous tumor antigens are acquired, processed, and cross-presented to CD8 T cells by DCs in tumor-bearing hosts is not well understood, but may have a profound effect on antitumor immunity. In this paper, we have examined the role of DCs in the cross-presentation of tumor antigen in terms of their subset, function, migration, and location with the intention of examining the early processes that contribute to the development of an ineffective anti-tumor immune response. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DENDRITIC cells
*ANTIGENS
*T cells
*TUMORS
*IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 17402522
- Database :
- Academic Search Index
- Journal :
- Clinical & Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 85599202
- Full Text :
- https://doi.org/10.1155/2010/539519