Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis.

The article presents a study which investigates the function of the vascular endothelial adrenomedullin (AM)-receptor activity-modifying protein 2 (RAMP2) in the organ homeostasis and vascular integrity. It states that RAMP2 mice were crossed breed with mice expressing tamoxifen-inducible Cre-recombinase (Cre-ERT2) to create RAMP2 conditional knockout (KO) mice. Results shows that the AM-RAMP2 system is the key factor of homeostasis and vascular integrity from prenatal levels through adulthood.