Interruption médicale de grossesse chez une patiente atteinte d’une mucoviscidose sévère. Impact potentiel de l’effet antiglucocorticoïde de la mifépristone sur la pathologie respiratoire

Abstract: Better management of patients with cystic fibrosis has resulted in an increased rate of pregnancy, especially in mild forms. In case of severe respiratory impairment, physiological changes occurring during pregnancy can be life threatening. Medical termination of pregnancy may be necessary. We report a case of severe cystic fibrosis requiring a termination of pregnancy due to significant maternal risk at 17 weeks of gestation. Mifepristone used for induction of labor has a well-known antiglucocorticoid action. We discuss here its potential effect on the onset of an acute pulmonary failure in this patient with long-term corticosteroid therapy. [Copyright &y& Elsevier]