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Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation.
- Source :
-
BMC Immunology . 2013, Vol. 14 Issue 1, p1-10. 10p. 1 Chart, 8 Graphs. - Publication Year :
- 2013
-
Abstract
- Background: It has been shown that human immunodeficiency virus (HIV)-1 infection induces the production of endogenous lipids required for effective viral production, and the cluster of differentiation (CD)1 molecule CD1d is downregulated by HIV-1 infection. However, the role of endogenous lipid presentation and the implications of CD1 downregulation by HIV-1 infection have not yet been characterized. Results: In this study, we observed downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced production of host cholesterol decreased the extent of CD1c and CD1d modulation. While the modest downregulation of CD1c by HIV-1 infection decreased the ability of CD1c-restricted T cells to respond and secrete interferon-γ, the cholesterol upregulation in the same cells by HIV-1 infection appears to limit the downregulation of CD1c. Conclusions: The two conflicting HIV-1-mediated changes in CD1c expression appear to minimize the modulation of CD1c expression, thus leading the host to maintain a CD1c-restricted T-cell response against HIV-1. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712172
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 85953507
- Full Text :
- https://doi.org/10.1186/1471-2172-14-4