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Association between transforming growth factor-α polymorphism and ankylosing spondylitis: a meta-analysis update.
- Source :
-
Modern Rheumatology . Mar2013, Vol. 23 Issue 2, p334-344. 11p. - Publication Year :
- 2013
-
Abstract
- Objectives: The reported results of the relationship between genetic polymorphisms of tumor necrosis factor (TNF)-α −238, −308 locus and ankylosing spondylitis (AS) susceptibility are not always consistent. This article aims to perform a meta-analysis to collect all the relevant studies to date to further clarify the relationship between those genetic polymorphisms and AS. Methods: A computer search was carried out up to September 2011 for literature pertaining to AS and TNF-α polymorphisms. Results: Twenty-two articles were included, with 2,506 cases of AS and 3,023 normal controls. We searched for genotypes A allele vs. G allele, AA vs. GG + GA, and GA + AA vs. GG in a fixed/random-effects model. The effect summary odds ratios (ORs) and 95 % confidence intervals (CIs) were obtained, which shows there was no association between genetic polymorphisms and AS. As the heterogeneity was observed, in a subgroup analysis by ethnicity, the degree of risk of two genes with AS susceptibility was similar in populations of European and Asian origin. For the human leukocyte antigen (HLA)-B27+ population, results were not statistically significant. Conclusion: ORs of various comparisons indicate that there is no association between TNF-α −238, −308 polymorphisms and AS susceptibility in the overall population and in the subgroup of Asian and non-Asian descent. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14397595
- Volume :
- 23
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Modern Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 85986489
- Full Text :
- https://doi.org/10.3109/s10165-012-0659-0