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The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2.
- Source :
-
Retrovirology . 2012, Vol. 9 Issue 1, p103-106. 4p. 1 Diagram. - Publication Year :
- 2012
-
Abstract
- Human T-cell Leukemia Virus type 1 (HTLV-1) and 2 (HTLV-2) are two closely related human retroviruses. HTLV-1 is associated with an aggressive Adult T-cell Leukemia (ATL) while there is no evidence for an association of HTLV-2 with any human malignancies. The two viruses encode transactivator proteins, Tax-1 and Tax-2 respectively. In ATL, Tax-1 is thought to play a central role in the transformation of a normal T-cell into a leukemic cell; however, it has not been entirely clear how post-translational modifications of Tax-1 influence its transforming activity. Here, we discuss three recent papers that report on the ubiquitination and sumoylation of Tax-1 and Tax-2. We comment on their divergent findings implicating the importance (or lack of importance) of these modifications and other events on Tax activation of NF-κB as related to cellular transformation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *UBIQUITINATION
*T cells
*LEUKEMIA
*RETROVIRUSES
*CELL transformation
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 9
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 86003277
- Full Text :
- https://doi.org/10.1186/1742-4690-9-103