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Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2013, Vol. 23 Issue 7, p2061-2064. 4p. - Publication Year :
- 2013
-
Abstract
- Abstract: A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd–DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T 1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 23
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 86154789
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.02.008