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BF3·OEt2-promoted concise synthesis of difluoroboron-derivatized curcumins from aldehydes and 2,4-pentanedione
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2013, Vol. 54 Issue 16, p2070-2073. 4p. - Publication Year :
- 2013
-
Abstract
- Abstract: A concise and one-pot cascade method has been developed to achieve the synthesis of difluoroboron-derivatized curcumins (BF2C). Treatment of 2,4-pentanedione with BF3·OEt2, followed by condensation with aldehydes in the presence of tributyl borate and butylamine at 65°C in toluene furnished the corresponding symmetric (s-BF2C) and unsymmetric difluoroboron-derivatized curcumins (us-BF2C) in good (60–99%) and moderate yields (23–42%) within 6–12h, respectively. [Copyright &y& Elsevier]
- Subjects :
- *CHEMICAL derivatives
*ALDEHYDES
*CURCUMIN
*PENTANEDIONE
*SYMMETRY (Physics)
*TOLUENE
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 54
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 86155526
- Full Text :
- https://doi.org/10.1016/j.tetlet.2013.02.015