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Architecture of the Spliceosome.
- Source :
-
Biochemistry . 4/24/2012, Vol. 51 Issue 16, p3321-3333. 13p. - Publication Year :
- 2012
-
Abstract
- Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human U1 snRNP. This review provides an overview of our current understanding of the architecture of the spliceosome and the RNA–protein complexes integral to its function, the U snRNPs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 51
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 86162218
- Full Text :
- https://doi.org/10.1021/bi201215r