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Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate
- Source :
-
European Journal of Obstetrics & Gynecology & Reproductive Biology . Jan2003, Vol. 106 Issue 1, p14-19. 6p. - Publication Year :
- 2003
-
Abstract
- Objective: To compare the maternal and fetal side effects of transdermal nitroglycerin and intravenous fenoterol combined with magnesium sulfate in a prospective randomised study. Study design: Fifty pregnant women between 27 and 35 weeks of gestation with preterm labour were treated with either nitroglycerin (0.4–0.8 mg/h) or fenoterol (60 – 120 μg/h). Outcome parameters were (1) the effects on fetal and maternal heart frequency (FHF / MHF) and blood pressure, and (2) subjective experiences of adverse effects assessed by utilising a questionnaire. Results: In the fenoterol group, elevated mean MHF, FHF and systolic blood pressure were recorded compared to nitroglycerin. Fewer maternal side effects were reported in the nitroglycerin group. Palpitations (82%), tremor (68%) and restlessness (64%) were most common in the fenoterol group (two drop-outs), whereas nitroglycerin caused headaches in 71% of the cases (four drop-outs). Conclusion: Transdermal nitroglycerin appears to be a safe therapy for the mother and fetus and is a promising new option for the treatment of preterm labour. [Copyright &y& Elsevier]
- Subjects :
- *PREGNANT women
*NITROGLYCERIN
*FENOTEROL
*ORCIPRENALINE
*FETAL heart rate
*BLOOD pressure
*MAGNESIUM sulfate
*RESEARCH
*COMBINATION drug therapy
*CLINICAL trials
*RESEARCH methodology
*TOCOLYTIC agents
*TRANSDERMAL medication
*EVALUATION research
*MEDICAL cooperation
*SEVERITY of illness index
*DRUG administration
*TREMOR
*COMPARATIVE studies
*RANDOMIZED controlled trials
*HUMAN reproductive technology
*HEART beat
*QUESTIONNAIRES
*INTRAVENOUS injections
*HEADACHE
*PREMATURE labor
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 03012115
- Volume :
- 106
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Journal of Obstetrics & Gynecology & Reproductive Biology
- Publication Type :
- Academic Journal
- Accession number :
- 8622861
- Full Text :
- https://doi.org/10.1016/S0301-2115(02)00197-5