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Differential Requirements for HIV-1 Vif-Mediated APOBEC3G Degradation and RUNX1-Mediated Transcription by Core Binding Factor Beta.
- Source :
-
Journal of Virology . Feb2013, Vol. 87 Issue 3, p1906-1911. 6p. - Publication Year :
- 2013
-
Abstract
- Core binding factor beta (CBFß), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFß. We also revealed that different lengths and regions are required for CBFß to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*AMINO acids
*GENETIC transcription
*ORGANIC acids
*BINDING sites
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 87
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 86276676
- Full Text :
- https://doi.org/10.1128/JVI.02199-12