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Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists, A-86929, and dihydrexidine
- Source :
-
Tetrahedron: Asymmetry . Mar2013, Vol. 24 Issue 5/6, p278-284. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available l -serine. The synthesis of A-86929 involves only one chromatographic purification. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 24
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 86370325
- Full Text :
- https://doi.org/10.1016/j.tetasy.2013.02.003