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Fluorescence ON/OFF switching Zn2+ sensor based on pyridine–pyridone scaffold
- Source :
-
Sensors & Actuators B: Chemical . May2013, Vol. 181, p823-828. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: We report a novel series of fluorescent Zn2+ sensors based on a pyridine–pyridone core structure, which functions as both the chelating part for Zn2+ and as the fluorophore. Pyridine–pyridone derivatives obtained by replacement of an electron-donating group with an electronic-withdrawing group at the 3-position of the pyridone ring showed almost no background fluorescence because electron transfer to the fluorophore was inhibited. However, these derivatives showed strong fluorescence with Zn2+. Coordination with Zn2+ greatly influenced the electron transfer of the fluorophore, and, as a result, enabled fluorescence ON/OFF switching. In these sensors, 4-[4-(methylsulfanyl)-2-oxo-6-(pyridin-2-yl)-1,2-dihydropyridin-3-yl]benzoic acid (5) displayed excellent properties: small molecular weight (MW=338), good water solubility, large Stokes shift (132nm), and fluorescence ON/OFF switching with Zn2+. In addition, fluorescence images of Zn2+ with 5 in living cells show that the new fluorescent sensor is useful for biological applications. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 181
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 86674788
- Full Text :
- https://doi.org/10.1016/j.snb.2013.02.033