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Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6.
- Source :
-
Alcohol . 2013, Vol. 47 Issue 3, p223-229. 7p. - Publication Year :
- 2013
-
Abstract
- Alcohol consumption leads to an exaggerated inflammatory response after burn injury. Elevated levels of interleukin-6 (IL-6) in patients are associated with increased morbidity and mortality after injury, and high systemic and pulmonary levels of IL-6 have been observed after the combined insult of ethanol exposure and burn injury. To further investigate the role of IL-6 in the pulmonary inflammatory response, we examined leukocyte infiltration and cytokine and chemokine production in the lungs of wild-type and IL-6 knockout mice given vehicle or ethanol (1.11 g/kg) and subjected to a sham or 15% total body surface area burn injury. Levels of neutrophil infiltration and neutrophil chemoattractants were increased to a similar extent in wild-type and IL-6 knockout mice 24 h after burn injury. When ethanol exposure preceded the burn injury, however, a further increase of these inflammatory markers was seen only in the wild-type mice. Additionally, signal transducer and activator of transcription-3 (STAT3) phosphorylation did not increase in response to ethanol exposure in the IL-6 knockout mice, in contrast to their wild-type counterparts. Visual and imaging analysis of alveolar wall thickness supported these findings and similar results were obtained by blocking IL-6 with antibody. Taken together, our data suggest a causal relationship between IL-6 and the excessive pulmonary inflammation observed after the combined insult of ethanol and burn injury. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07418329
- Volume :
- 47
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Alcohol
- Publication Type :
- Academic Journal
- Accession number :
- 86682957
- Full Text :
- https://doi.org/10.1016/j.alcohol.2013.01.004