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Variation in tau isoform expression in different brain regions and disease states
- Source :
-
Neurobiology of Aging . Jul2013, Vol. 34 Issue 7, p1922.e7-1922.e12. 0p. - Publication Year :
- 2013
-
Abstract
- Abstract: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance has been strongly implicated as a cause of disease. Thus, understanding tau isoform regional expression in disease and pathology-free states is crucial to elucidating the mechanisms involved in PSP and other tauopathies. We used a tau isoform-specific fluorescent assay to investigate relative 4R-tau expression in 6 different brain regions in PSP cases and healthy control samples. We identified a marked difference in 4R-tau relative expression, across brain regions and between MAPT haplotypes. Highest 4R-tau expression levels were identified in the globus pallidus compared with pons, cerebellum, and frontal cortex. 4R-tau expression levels were related to the MAPT H1 and H1c haplotypes. Similar regional variation was seen in PSP case and in control samples. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01974580
- Volume :
- 34
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Aging
- Publication Type :
- Academic Journal
- Accession number :
- 86885269
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2013.01.017