SYNTHESIS OF N-PROTECTED PEPTIDE ALCOHOLS CATALYZED BY SUBTILISIN OR α-CHYMOTRYPSIN IN ORGANIC SOLVENTS.

A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or α-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied. [ABSTRACT FROM AUTHOR]