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Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially.
- Source :
-
Clinical & Experimental Immunology . Jun2013, Vol. 172 Issue 3, p466-474. 9p. 5 Charts. - Publication Year :
- 2013
-
Abstract
- The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination ( FCD) and (ii) sibship structure in relation to an autoimmune ( FCD) and an allergic (asthma) disease. FCD cases ( n = 282) were aged 18-59 years; controls ( n = 558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio ( OR) = 3·11; 95% confidence interval ( CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD ( OR = 0·68; 95% CI: 0·49, 0·95) but not asthma ( OR = 1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma ( P trend = 0·04) but not FCD ( P trend = 0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 172
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 87042998
- Full Text :
- https://doi.org/10.1111/cei.12077