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The Disturbance of Hippocampal Ca MKII/ PKA/ PKC Phosphorylation in Early Experimental Diabetes Mellitus.
- Source :
-
CNS Neuroscience & Therapeutics . May2013, Vol. 19 Issue 5, p329-336. 8p. - Publication Year :
- 2013
-
Abstract
- Background Defining the impact of diabetes and related risk factors on brain cognitive function is critically important for patients with diabetes. Aims To investigate the alterations in hippocampal serine/threonine kinases signaling in the early phase of type 1 and type 2 diabetic rats. Methods Early experimental diabetes mellitus was induced in rats with streptozotocin or streptozotocin/high fat. Changes in the phosphorylation of proteins were determined by immunoblotting and immunohistochemistry. Results Our data showed a pronounced decrease in the phosphorylation of Ca2+/calmodulin-dependent protein kinase II (Ca MKII) in the hippocampi of both type 1 and type 2 diabetic rats compared with age-matched control rats. Unexpectedly, we found a significant increase in the phosphorylation of synapsin I ( Ser 603) and Glu R1 ( Ser 831) in the same experiment. In addition, aberrant changes in hippocampal protein kinase C ( PKC) and protein kinase A ( PKA) signaling in type 1 and type 2 diabetic rats were also found. Moreover, PP1α and PP2 A protein levels were decreased in the hippocampus of type 1 diabetic rats, but significantly up-regulated in type 2 diabetic rats. Conclusions The disturbance of Ca MKII/ PKA/ PKC phosphorylation in the hippocampus is an early change that may be associated with the development and progression of diabetes-related cognitive dysfunction. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17555930
- Volume :
- 19
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- CNS Neuroscience & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 87089849
- Full Text :
- https://doi.org/10.1111/cns.12084