Back to Search
Start Over
2′-C-ALKOXY AND 2′-C-ARYLOXY DERIVATIVES OF N-(2-PHOSPHONOMETHOXYETHYL)-PURINES AND -PYRIMIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY.
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . Aug2001, Vol. 20 Issue 8, p1497-1522. 26p. 2 Charts. - Publication Year :
- 2001
-
Abstract
- A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOSPHONATES
*NUCLEOTIDES
*ANTIVIRAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 20
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 8739425
- Full Text :
- https://doi.org/10.1081/NCN-100105244