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Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report.
- Source :
-
Diabetology & Metabolic Syndrome . 2013, Vol. 5 Issue 1, p1-5. 5p. 2 Charts, 1 Graph. - Publication Year :
- 2013
-
Abstract
- Background: Atherosclerosis is an age-related disease. Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated circulating C1q and C1q-APN levels in Japanese men including elderly men. Findings: The study subjects were 509 Japanese men including elderly men. Serum levels of total adiponectin (Total-APN), high-molecular weight-adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assay. Total-APN, HMW-APN and C1q-APN, but not C1q, correlated significantly and positively with aging (r=0.26, r=0.24, r=0.17, p<0.01, respectively). The HMW-APN/Total-APN ratio correlated significantly and positively with aging (r=0.14, p<0.01). The C1q-APN/Total-APN ratio and C1q-APN/HMW-APN ratio correlated significantly and negatively with aging (r=-0.17, p<0.01, r=-0.12, p=0.01). C1q-APN/C1q correlated significantly and positively with aging (r=0.09, p=0.03). Multiple regression analysis identified age and body mass index as significant determinants of C1q-APN. Conclusions: The present study demonstrates that serum HMW-APN, C1q-APN, and Total-APN, but not C1q, correlated positively with aging. These preliminary results could form the basis for future research. Trial registration: Clinical Trial Registration Number: UMIN000004318 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17585996
- Volume :
- 5
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diabetology & Metabolic Syndrome
- Publication Type :
- Academic Journal
- Accession number :
- 87466998
- Full Text :
- https://doi.org/10.1186/1758-5996-5-17