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Usefulness of Urinary Immune Biomarkers in the Evaluation of Neonatal Sepsis: A Pilot Project.
- Source :
-
Clinical Pediatrics . Jun2013, Vol. 52 Issue 6, p520-526. 7p. - Publication Year :
- 2013
-
Abstract
- Objective. Our hypothesis is that specific proinflammatory and anti-inflammatory urinary cytokines are useful in the diagnostic evaluation of risk for sepsis in term neonates. We conducted a pilot, prospective hospital-based longitudinal observational study to test the urine of term neonates with a 13 biomarker panel of cytokines. Methods. Infants were divided into 2 groups: The control group (n = 15) consisted of infants admitted to newborn nursery, and the test group (n = 15) consisted of infants admitted to the neonatal intensive care unit for presumed sepsis. Bagged urine samples were collected from 30 term neonates for testing our hypothesis. Results. Urinary interleukin (IL)-8 (P = .004*), inducible protein (IP)-10 (P = .007*), and monocyte chemoattractant protein (MCP)-1 (P = .02) were significantly increased in the test group compared with the control group. Conclusions. Urinary IL-8, IP-10, and MCP-1 are proinflammatory cytokines that are increased in the neonate during an infectious inflammatory process. These may be useful predictors as an adjunct to the current protocols to recognize neonatal sepsis. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *SEPSIS
*BIOMARKERS
*CHI-squared test
*CYTOKINES
*INTERVIEWING
*LONGITUDINAL method
*NEONATAL intensive care
*SCIENTIFIC observation
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*PILOT projects
*DATA analysis
*NEONATAL intensive care units
*DATA analysis software
*DESCRIPTIVE statistics
*DIAGNOSIS
DIAGNOSIS of neonatal diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00099228
- Volume :
- 52
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Clinical Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 87499852
- Full Text :
- https://doi.org/10.1177/0009922813482751