Primary intracranial yolk sac tumor in the posterior fossa: Case report of a child with Down syndrome.

The article describes the case of a two and a half year old boy diagnosed with Down syndrome (DS) who was diagnosed with primary intracranial yolk sac tumor (YST) in the posterior fossa. Systemic chemotherapy was initiated after tumor resection and no tumor recurrence or elevated serum α fetoprotein (AFP) was reported in one an d a half years. It concluded that dose-reduction multidrug chemotherapy is the standard treatment for acute myeloid leukemia in DS.