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Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34
- Source :
-
Biochemical & Biophysical Research Communications . Jan2003, Vol. 300 Issue 3, p789. 4p. - Publication Year :
- 2003
-
Abstract
- The human homolog of the Drosophila discs large tumor suppressor protein (hDLG) functions as a scaffolding protein that facilitates the transmission of diverse downstream signals. Here we show that hDLG interacts through its PDZ domains with the carboxy-terminal S/TXV motif of the mitochondrial ribosomal protein S-34 (MRP-S34). Our results suggest that hDLG interacts with MRP-S34 prior to entry of MRP-S34 into the mitochondria and may be involved in the trafficking of MRP-S34. [Copyright &y& Elsevier]
- Subjects :
- *DROSOPHILA
*TUMOR suppressor genes
*PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 300
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 8763381
- Full Text :
- https://doi.org/10.1016/S0006-291X(02)02887-5