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Protein Analysis by Shotgun/Bottom-up Proteomics.
- Source :
-
Chemical Reviews . Apr2013, Vol. 113 Issue 4, p2343-2394. 52p. - Publication Year :
- 2013
-
Abstract
- The article discusses the technique of shotgun/ bottom-up proteomics for the analysis of protein. It states that bottom-up process characterizes protein by analyzing the peptides released from the protein through proteolysis. It discusses several techniques related to shotgun proteomics which include two dimensional polyacrylamide gel electrophoresis (20-PAGE), chromatographic methods and post-translational modification (PTM) analysis by Mass Spectrometry.
Details
- Language :
- English
- ISSN :
- 00092665
- Volume :
- 113
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Chemical Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 87644319
- Full Text :
- https://doi.org/10.1021/cr3003533