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Inverse problems in neuronal calcium signaling.

Authors :
Raol, Jay
Cox, Steven
Source :
Journal of Mathematical Biology. Jul2013, Vol. 67 Issue 1, p3-23. 21p.
Publication Year :
2013

Abstract

Calcium is the most important of the brain's second messengers. Thanks to engineered fluorescent indicators and caged compounds we have an excellent qualitative picture of its regulation and impact. With the advent of new scanning technology that permits one to observe the calcium signal throughout a highly branched neuron the potential exists for functional, single cell, quantitative calcium imaging. To help realize that potential we analyze a sequence of four inverse problems that infer the parameters of the cytosolic calcium buffers and plasma membrane calcium pumps and channels from the light shed by fluorescent indicators following specific stimulus protocols. Our analyses lead in each case to practical algorithms that we illustrate and test on synthetic data. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03036812
Volume :
67
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Mathematical Biology
Publication Type :
Academic Journal
Accession number :
88109949
Full Text :
https://doi.org/10.1007/s00285-012-0507-z