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Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming.
- Source :
-
Nature Medicine . May1999, Vol. 5 Issue 5, p565. 7p. - Publication Year :
- 1999
-
Abstract
- Variation in epitopes of infectious pathogens inhibits various effector functions of T lymphocytes through antagonism of the T-cell receptor. However, a more powerful strategy for immune evasion would be to prevent the induction of T-cell responses. We report here mutual 'interference' with the priming of human T-cell responses by a pair of naturally occurring variants of a malaria cytotoxic T-cell epitope. Interference with priming also occurs in vivo for a murine malaria T-cell epitope. Reshaping of the T-cell repertoire by such immune interference during naive T-cell induction may provide a general mechanism for observed patterns of immunodominance and persistence by many polymorphic pathogens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELLULAR immunity
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 5
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8821776
- Full Text :
- https://doi.org/10.1038/8444