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An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity.
- Source :
-
Journal of Antimicrobial Chemotherapy (JAC) . Jul2013, Vol. 68 Issue 7, p1655-1659. 5p. - Publication Year :
- 2013
-
Abstract
- Objectives The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to a distinct cytokine profile in patients receiving amphotericin B deoxycholate (AmBD). Patients and methods In 58 patients who received AmBD, circulating serum interleukin (IL)-6, IL-8 and IL-10 were measured at baseline, week 1 and week 2 of antifungal treatment and correlated to the development of renal impairment. The Cox proportional hazards model approach was adopted for analysis. Results The P value was 0.026 for the overall effect of IL-6 on time to development of AKI. An increasing or non-receding IL-6 trend by week 1 of AmBD treatment (followed by a decreasing or non-receding IL-6 trend from week 1 to week 2) correlated with an increased likelihood of nephrotoxicity [hazard ratio (HR) 6.93, P value 0.005 and HR 3.46, P value 0.035, respectively]. Similarly, persistently increasing IL-8 levels were linked to a 3.84-fold increased likelihood of AKI. Conclusions In patients receiving AmBD, persistence of an elevated pro-inflammatory cytokine milieu is associated with a predisposition to drug-related kidney injury. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *CYTOKINES
*CELLULAR immunity
*AMPHOTERICIN B
*AMPHOTERICINS
*NEPHROTOXICOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03057453
- Volume :
- 68
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Academic Journal
- Accession number :
- 88269511
- Full Text :
- https://doi.org/10.1093/jac/dkt055