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B7-H3: A costimulatory molecule for T cell activation and IFN-γ production.
- Source :
-
Nature Immunology . Mar2001, Vol. 2 Issue 3, p269. 6p. - Publication Year :
- 2001
-
Abstract
- We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20?27% amino acid identity with other B7 family members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin. Soluble B7-H3 protein binds a putative counter-receptor on activated T cells that is distinct from CD28, cytotoxic T lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction of cytotoxic T cells and selectively stimulates interferon γ (IFN-γ) production in the presence of T cell receptor signaling. In contrast, inclusion of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and inhibits IFN-γ production by DC-stimulated allogeneic T cells. Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediated immune responses. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cell receptors
*MESSENGER RNA
*TUMOR lipids
*CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 2
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8837644
- Full Text :
- https://doi.org/10.1038/85339