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Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model.

Authors :
Geng, Wenxin
Yan, Xingrong
Du, Huicong
Cui, Jihong
Li, Liwen
Chen, Fulin
Source :
Biochemical & Biophysical Research Communications. May2013, Vol. 434 Issue 2, p280-286. 7p.
Publication Year :
2013

Abstract

Highlights: [•] A GST-FSH fusion protein was successfully expressed in E. coli. [•] Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. [•] Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. [•] FSH immunization can prevent bone loss in a rat osteoporosis model. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
434
Issue :
2
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
88983688
Full Text :
https://doi.org/10.1016/j.bbrc.2013.02.116