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Simvastatin attenuates the additive effects of TNF-α and IL-18 on the connexin 43 up-regulation and over-proliferation of cultured aortic smooth muscle cells.
- Source :
-
Cytokine . Jun2013, Vol. 62 Issue 3, p341-351. 11p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] This study investigates the role of IL-18 in cultured aortal smooth muscle cells. [•] IL-18 up-regulates Cx43 expression in TNF-α dependent manner. [•] IL-18 additively enhances TNF-α-stimulated cell proliferation. [•] Statin reduces the additive effects via Akt blockade. [•] These findings fortify the atheroprotective mechanism of statin therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10434666
- Volume :
- 62
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 88985034
- Full Text :
- https://doi.org/10.1016/j.cyto.2013.04.003