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AG490 inhibits NFATc1 expression and STAT3 activation during RANKL induced osteoclastogenesis.
- Source :
-
Biochemical & Biophysical Research Communications . Jun2013, Vol. 435 Issue 4, p533-539. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] AG490 inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells. [•] AG490 affects cell proliferation and cell cycle distribution. [•] AG490 reduces NFATc1 expression during RANKL-induced osteoclastogenesis. [•] AG490 disrupts the activation of RANKL-mediated JAK2/STAT3 signaling pathway. [•] STAT3 depletion partly mimics the effect of AG490 on RANKL-induced osteoclastogenesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 435
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 88987480
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.04.084