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Evolution of the melanocortin-2 receptor in tetrapods: Studies on Xenopus tropicalis MC2R and Anolis carolinensis MC2R.
- Source :
-
General & Comparative Endocrinology . Jul2013, Vol. 188, p75-84. 10p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] xtMC2R and acMC2R can be functionally expressed in CHO cells if a tetrapod MRAP1 ortholog is co-expressed. [•] Alanine substitution at any position in the H6F7R8W9 motif of ACTH(1–24) will block the activation of either xtMC2R or acMC2R. [•] The 2° structure of the G10K11P12V13G14 motif in ACTH(1–24) is important for the activation of xtMC2R and acMC2R. [•] Alanine substitution at either the K15K16 or the R17R18P19 motif in ACTH(1–24) disrupts activation of xtMC2R or acMC2R. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00166480
- Volume :
- 188
- Database :
- Academic Search Index
- Journal :
- General & Comparative Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 89034094
- Full Text :
- https://doi.org/10.1016/j.ygcen.2013.04.007