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Asymmetric synthesis of potent glycosidase and very potent α-mannosidase inhibitors: 4-amino-4-deoxy-l-erythrose and 4-amino-4,5-dideoxy-l-ribose
- Source :
-
Tetrahedron . Jan2003, Vol. 59 Issue 4, p543. 11p. - Publication Year :
- 2003
-
Abstract
- Pyrrolidine amino-sugars, cyclic iminoalditols as well as linear aminoalditols in 4-amino-l-erythrose and 4-amino-5-deoxy-l-ribose series were synthesised by asymmetric hetero-Diels–Alder reaction followed by chemical transformations. 4-Amino-4-deoxy-l-erythrose and 4-amino-4,5-dideoxy-l-ribose were potent β-d-glucosidase, α-d-mannosidase, α- and β-d-galactosidase inhibitors. We have shown that the ribose derivative was a very potent inhibitor of α-d-mannosidase. [Copyright &y& Elsevier]
- Subjects :
- *AMINO sugars
*MANNOSIDASES
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 59
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 8903698
- Full Text :
- https://doi.org/10.1016/S0040-4020(02)01512-0