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CD133+/CD44+/Oct4+/Nestin+ stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer.

Authors :
Wang, Dongqing
Zhu, Haitao
Zhu, Ying
Liu, Yanfang
Shen, Huiling
Yin, Ruigen
Zhang, Zhijian
Su, Zhaoliang
Source :
Acta Histochemica. May2013, Vol. 115 Issue 4, p349-356. 8p.
Publication Year :
2013

Abstract

Abstract: Pancreatic cancer is an aggressive malignant disease. Owing to the lack of early symptoms, accompanied by extensive metastasis and high resistance to chemotherapy, pancreatic adenocarcinoma becomes the fourth leading cause of cancer-related deaths. In this study, we identified a subpopulation of cells isolated from the Panc-1 cell line and named pancreatic cancer stem-like cells. These Panc-1 stem-like cells expressed high levels of CD133/CD44/Oct4/Nestin. Compared to Panc-1 cells, Panc-1 stem-like cells were resistant to gemcitabine and expressed high levels of MDR1; furthermore, Panc-1 stem-like cells have high anti-apoptotic, but weak proliferative potential. These results indicated that Panc-1 stem-like cells, as a novel group, may be a potential major cause of pancreatic cancer multidrug resistance and extensive metastasis. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00651281
Volume :
115
Issue :
4
Database :
Academic Search Index
Journal :
Acta Histochemica
Publication Type :
Academic Journal
Accession number :
89070051
Full Text :
https://doi.org/10.1016/j.acthis.2012.09.007