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Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds.

Authors :
Rhoden, Eric
Liu, Hong-Mei
Wang-Chern, Shur-wern
Oberste, M. Steven
Source :
Antiviral Research. May2013, Vol. 98 Issue 2, p186-191. 6p.
Publication Year :
2013

Abstract

Highlights: [•] Antivirals are needed to treat immunodeficient chronic poliovirus excretors. [•] Picornavirus protease inhibitor AG-7404 is active against 45 poliovirus strains. [•] AG-7404 acts synergistically with either of two poliovirus capsid inhibitors. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01663542
Volume :
98
Issue :
2
Database :
Academic Search Index
Journal :
Antiviral Research
Publication Type :
Academic Journal
Accession number :
89089565
Full Text :
https://doi.org/10.1016/j.antiviral.2013.03.003